New cranial material of Mesturus cordillera Martill et al., 1998 from the Oxfordian of Quebrada del Profeta locality of northern Chile allows a detailed study of the jaw apparatus and some additional cranial bones. The tooth morphology in combination with a short and pyriform edentulous maxilla refers the species to the pycnodont fish genus Gyrodus Agassiz, 1833. The available material is not sufficient for a specific determination. therefore, the taxon is left as Gyrodus sp. (=Mesturus cordillera). This is the first species of Gyrodus known from the Upper Jurassic of South America. A second Gyrodus species, G. macrophthalmus cubensis Gregory, 1923, is known from the Upper Jurassic of Cuba. The stratigraphic and biogeographic occurrences of Gyrodus are discussed and the genus Mesturus Wagner, 1862 is thus restricted to the Jurassic of Europe.